Gamma-aminobutyric acid (GABA) is a major neurotransmitter widely distributed throughout the central nervous system. Because too much excitation can lead to irritability, restlessness, sleeplessness, and spasmodic movements, this excitation needs to be balanced with inhibition. GABA – the most important inhibitory neurotransmitter in the brain – can provide this inhibition, acting like a "brake" during times of runaway stress.* In addition, studies also indicate GABA can promote relaxation and enhance sleep.* It is thought that either low GABA levels or decreased GABA function in the brain may have an adverse impact on neurological health.*

The natural GABA in Thorne's PharmaGABA-250 is produced via a fermentation process that utilizes Lactobacillus hilgardii, the bacteria used to ferment vegetables in the preparation of the traditional Korean cabbage dish known as kimchi. Clinical studies show this natural form of GABA can increase the production of alpha-waves in the brain, creating a profound sense of physical relaxation while maintaining mental focus.* In contrast, the stress-related beta-waves in the brain are decreased.* In addition to changes in brain waves, natural PharmaGABA has been shown to produce relaxation, as evidenced by reduced pupil diameter, heart rate, and two natural markers of stress – salivary cortisol and chromogranin A.* In a head-to-head, double-blind trial of natural PharmaGABA versus synthetic GABA, synthetic GABA did not demonstrate these positive effects.